[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

Base Information

Chemical Name:[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid
CAS No.:1375082-86-2
Molecular Formula:C₁₃H₁₈ClNO₈P₂
Molecular Weight:413.688
Hs Code.:

Synonyms:[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

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Chemical Property of [(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

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Technology Process of [(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

There total 4 articles about [(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (x)C₆H₁₅N*C₁₇H₂₅ClN₂O₈P₂

: 1375082-86-2
[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

Guidance literature:: (x)C₆H₁₅N*C₁₇H₂₅ClN₂O₈P₂; In water; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; for 0.5h;
DOI:10.1021/ja300218x

Reference yield:

: 1375142-33-8
(2S)-2-({[chloro(phosphono)methyl](hydroxy)phosphoryl}oxy)-2-phenylacetic acid

: 1375082-86-2
[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; tert-butyl alcohol / 0.25 h / 20 °C

1.2: 5 h / Reflux

1.3: pH 7.4

2.1: cation exchange Dowex resin / water / 0.5 h / 20 °C

2.2: 0.5 h

With cation exchange Dowex resin; In water; tert-butyl alcohol;
DOI:10.1021/ja300218x

Reference yield:

: 15715-58-9
triethylamine carbonate

: 1375082-86-2
[(R)-chloro({hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl})methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; tert-butyl alcohol / 0.25 h / 20 °C

1.2: 5 h / Reflux

1.3: pH 7.4

2.1: cation exchange Dowex resin / water / 0.5 h / 20 °C

2.2: 0.5 h

With cation exchange Dowex resin; In water; tert-butyl alcohol;
DOI:10.1021/ja300218x