Technology Process of 4'-Hydroxy-3'-(pyridazin-4-yl)biphenyl-3-carbonitrile
There total 4 articles about 4'-Hydroxy-3'-(pyridazin-4-yl)biphenyl-3-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; cesium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 110 °C / Inert atmosphere
2: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 2 h / 0 - 20 °C
3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere
With
N-iodo-succinimide; copper(l) iodide; sulfuric acid; sodium carbonate; acetic acid; cesium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
1: Suzuki Coupling / 3: Stille Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 2 h / 0 - 20 °C
2: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere
With
N-iodo-succinimide; copper(l) iodide; sulfuric acid; acetic acid; cesium fluoride;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; N,N-dimethyl-formamide;
2: Stille Coupling;
