2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

Base Information

Chemical Name:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine
CAS No.:1362910-83-5
Molecular Formula:C₂₄H₂₃F₃N₆O
Molecular Weight:468.481
Hs Code.:

Synonyms:2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

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Chemical Property of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

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Technology Process of 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

There total 7 articles about 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: C₂₀H₁₄F₃N₅O

: 1362910-83-5
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

Guidance literature:: morpholine; C₂₀H₁₄F₃N₅O; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

With water; acetic acid;

Reference yield:

: 1241915-77-4
methyl 4-carbamoyl-3-(2,2-difluoro-2-(4-fluorophenyl)acetamido)benzoate

: 1362910-83-5
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloro-trimethyl-silane; triethylamine / 1,2-dichloro-ethane / 85 °C

2.1: trichlorophosphate / Reflux

3.1: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

4.2: 0 °C

5.1: Dess-Martin periodane; N,N-dimethyl acetamide / dichloromethane / 0 - 20 °C

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With lithium aluminium tetrahydride; chloro-trimethyl-silane; N,N-dimethyl acetamide; sodium tris(acetoxy)borohydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 35092-89-8
4-(methoxycarbonyl)-3-nitrobenzoic acid

: 1362910-83-5
2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide / 105 °C / Sealed tube

1.2: Reflux

1.3: 4 h / 20 °C / 760.05 Torr

2.1: HATU / N,N-dimethyl-formamide / 0.5 h

3.1: chloro-trimethyl-silane; triethylamine / 1,2-dichloro-ethane / 85 °C

4.1: trichlorophosphate / Reflux

5.1: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

6.2: 0 °C

7.1: Dess-Martin periodane; N,N-dimethyl acetamide / dichloromethane / 0 - 20 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With ammonium hydroxide; lithium aluminium tetrahydride; chloro-trimethyl-silane; N,N-dimethyl acetamide; sodium tris(acetoxy)borohydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;