N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

Base Information

Chemical Name:N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine
CAS No.:1610462-88-8
Molecular Formula:C₁₉H₁₉FN₄OS
Molecular Weight:370.45
Hs Code.:

Synonyms:N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

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Chemical Property of N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

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Technology Process of N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

There total 1 articles about N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179899-07-1
4-fluoro-2-methoxyphenylboronic acid

: 1610462-88-8
N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; water / 1,2-dimethoxyethane / 2.5 h / 90 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one; XPhos; potassium phosphate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct / toluene / 4 h / 130 °C / Inert atmosphere; Sealed tube

With 1-methyl-pyrrolidin-2-one; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; water; potassium carbonate; XPhos; In 1,2-dimethoxyethane; toluene;

Reference yield:

: 354-38-1
2,2,2-trifluoroacetamide

: 1610462-88-8
N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

: 1610462-89-9
(rac)-N-{ethyl[(2-{[6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-yl]amino}pyridin-4-yl)methyl]-λ⁴-sulfanylidene}-2,2,2-trifluoroacetamide

Guidance literature:: 2,2,2-trifluoroacetamide; With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium t-butanolate; In tetrahydrofuran; at -10 - 10 ℃; for 0.166667h; Inert atmosphere;

N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine; In tetrahydrofuran; at -10 ℃; for 0.833333h; Inert atmosphere;

Reference yield:

: 1610462-88-8
N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

: 1610462-79-7
(rac)-N-{4-[(S-ethylsulfonimidoyl)methyl]pyridin-2-yl}-6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 0.17 h / -10 - 10 °C / Inert atmosphere

1.2: 0.83 h / -10 °C / Inert atmosphere

2.1: potassium hydroxide; Oxone; water / methanol / 1.25 h / pH 7.8 - 8.2

With Oxone; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; potassium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol;