(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

Base Information

Chemical Name:(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide
CAS No.:1025766-66-8
Molecular Formula:C₃₀H₃₄FN₃O
Molecular Weight:471.618
Hs Code.:

Synonyms:(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

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Chemical Property of (S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

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Technology Process of (S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

There total 5 articles about (S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070-83-3
tert-Butylacetic acid

: 1025769-29-2
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropan-1-amine

: 1025766-66-8
(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

Guidance literature:: tert-Butylacetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropan-1-amine; In N,N-dimethyl-formamide; at 20 ℃; for 3 - 24h;

Reference yield:

: 1455513-16-2
C₂₄H₂₁FN₂O₂

: 1025766-66-8
(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 3 h

2: ammonia / tetrahydrofuran / 3 h / -78 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 50 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / 12 h

With pyridine; lithium aluminium tetrahydride; trifluoro-[1,3,5]triazine; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2013.06.085

Reference yield:

: C₂₄H₂₂FN₃O

: 1025766-66-8
(S)-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropyl)-3,3-dimethylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 50 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / 12 h

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2013.06.085