N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

Base Information

Chemical Name:N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide
CAS No.:380900-66-3
Molecular Formula:C₂₅H₃₄N₄O₃
Molecular Weight:438.57
Hs Code.:

<i>N</i>-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

Synonyms:N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

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Chemical Property of N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

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Technology Process of N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

There total 7 articles about N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 380900-65-2
N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

: 380900-66-3
N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/S0960-894X(03)00462-1

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 380900-66-3
N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 20 °C

2: methanol / 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: NaCNBH₃; AcOH / methanol

5: 100 percent / H₂ / Pd/C

With hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00462-1

Reference yield:

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 380900-66-3
N-{(2-amino-phenyl)-[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-methyl}-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / aq. NaOH; Bn(Et)3NCl / CH₂Cl₂ / 1.5 h / Heating

2: methanol / 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: NaCNBH₃; AcOH / methanol

5: 100 percent / H₂ / Pd/C

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00462-1