6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

Base Information

Chemical Name:6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole
CAS No.:1556025-13-8
Molecular Formula:C₄₃H₄₁O₂P
Molecular Weight:620.771
Hs Code.:

Synonyms:6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

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Chemical Property of 6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

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Technology Process of 6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

There total 5 articles about 6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₁H₈₁O₂PSi₂

: 1556025-13-8
6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3cc48943d

Reference yield:

: C₂₄H₂₈IO₂P

: 1556025-13-8
6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diisopropylamine / 0.25 h / 80 °C / Schlenk technique; Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc48943d

Reference yield:

: 1556025-07-0
(S_P)-5-hydroxy-1-(L-menthyl)-1-oxo-2-phenyl-1H-phosphindole

: 1556025-13-8
6-((2-(but-3-ynyl)naphthalen-1-yl)ethynyl)-1-(L-menthyl)-1-oxo-2-phenyl-5-(prop-2-ynyloxy)-1H-phosphindole

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / -78 - 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diisopropylamine / 0.25 h / 80 °C / Schlenk technique; Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc48943d