C₂₅H₃₃F₂N₃O₃

Base Information

Chemical Name:C₂₅H₃₃F₂N₃O₃
CAS No.:845546-59-0
Molecular Formula:C₂₅H₃₃F₂N₃O₃
Molecular Weight:461.552
Hs Code.:

C<sub>25</sub>H<sub>33</sub>F<sub>2</sub>N<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₅H₃₃F₂N₃O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₅H₃₃F₂N₃O₃

Chemical Property:

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Technology Process of C₂₅H₃₃F₂N₃O₃

There total 8 articles about C₂₅H₃₃F₂N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 845544-12-9
C₂₅H₃₁F₂N₃O₄

: 845546-59-0
C₂₅H₃₃F₂N₃O₃

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; Reflux;
DOI:10.1016/j.bmcl.2010.03.050

Reference yield:

: 473567-47-4
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluorophenyl)propanoate

: 845546-59-0
C₂₅H₃₃F₂N₃O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 - 70 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.67 h / -78 °C

4.2: 2 h / 20 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 °C

5.2: -78 - 20 °C

6.1: hydrogen / palladium hydroxide on carbon; acetic acid / ethanol / 5 h / 20 °C

7.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 60 °C / Heating

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide; diisopropylamine; palladium hydroxide on carbon; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 845543-61-5
(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal

: 845546-59-0
C₂₅H₃₃F₂N₃O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: -78 - 20 °C

2.1: hydrogen / palladium hydroxide on carbon; acetic acid / ethanol / 5 h / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 60 °C / Heating

With n-butyllithium; dimethylsulfide borane complex; hydrogen; diisopropylamine; palladium hydroxide on carbon; acetic acid; In tetrahydrofuran; ethanol; hexane;