2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

Base Information

Chemical Name:2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester
CAS No.:186132-75-2
Molecular Formula:C₁₉H₂₀N₂O₆S
Molecular Weight:404.444
Hs Code.:

Synonyms:2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

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Chemical Property of 2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

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Technology Process of 2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

There total 6 articles about 2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 186132-73-0
2-Bromomethyl-benzoic acid 4-nitro-benzyl ester

: 186132-75-2
2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; 0 deg C, 15 min; room temp., 3 h;
DOI:10.1002/hlca.19960790816

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 186132-75-2
2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / acetone / 4 h / Heating

2: 13 percent / N-bromosuccinimid / CCl₄ / 0.42 h / Heating; Irradiation

3: 50 percent / Et₃N / CH₂Cl₂ / 0 deg C, 15 min; room temp., 3 h

With N-Bromosuccinimide; potassium carbonate; triethylamine; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1002/hlca.19960790816

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 186132-75-2
2-((R)-2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-benzoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / (i-Pr)2EtN / CH₂Cl₂ / 0 deg C, 15 min; room temp., 3 h

2: 50 percent / Et₃N / CH₂Cl₂ / 0 deg C, 15 min; room temp., 3 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.19960790816