Technology Process of (4S,5R,6R,9S,10R)-1-(tert-butyldimethylsiloxy)-9-hydroxy-5-<(4-methoxybenzyl)oxy>-4,6,10-trimethyl-11-dodecene
There total 4 articles about (4S,5R,6R,9S,10R)-1-(tert-butyldimethylsiloxy)-9-hydroxy-5-<(4-methoxybenzyl)oxy>-4,6,10-trimethyl-11-dodecene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / Et3N / toluene; CH2Cl2 / 0.5 h / 0 °C
2: 88 percent / LiAlH4 / toluene; tetrahydrofuran / 1) rt, 10 min; 2) 60 deg C, 13 min
3: 1.) O3, 2.) tributylphosphine / 1) CH2Cl2, -78 deg C, 5 min; 2) CH2Cl2, rt, 2.5 h
4: 1.) potassium tert-butoxide, n-BuLi, (+)-methoxydiisopinocamphenylborane, 2.) BF3*OEt2, 3.) aq. H2O2
With
lithium aluminium tetrahydride; n-butyllithium; tributylphosphine; boron trifluoride diethyl etherate; potassium tert-butylate; dihydrogen peroxide; ozone; triethylamine; (+)-B-methoxydiisocamphenylborane;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo952083l
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / LiAlH4 / toluene; tetrahydrofuran / 1) rt, 10 min; 2) 60 deg C, 13 min
2: 1.) O3, 2.) tributylphosphine / 1) CH2Cl2, -78 deg C, 5 min; 2) CH2Cl2, rt, 2.5 h
3: 1.) potassium tert-butoxide, n-BuLi, (+)-methoxydiisopinocamphenylborane, 2.) BF3*OEt2, 3.) aq. H2O2
With
lithium aluminium tetrahydride; n-butyllithium; tributylphosphine; boron trifluoride diethyl etherate; potassium tert-butylate; dihydrogen peroxide; ozone; (+)-B-methoxydiisocamphenylborane;
In
tetrahydrofuran; toluene;
DOI:10.1021/jo952083l
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. H2O2, NaOH / 1 h / Ambient temperature
2: 94 percent / Et3N / toluene; CH2Cl2 / 0.5 h / 0 °C
3: 88 percent / LiAlH4 / toluene; tetrahydrofuran / 1) rt, 10 min; 2) 60 deg C, 13 min
4: 1.) O3, 2.) tributylphosphine / 1) CH2Cl2, -78 deg C, 5 min; 2) CH2Cl2, rt, 2.5 h
5: 1.) potassium tert-butoxide, n-BuLi, (+)-methoxydiisopinocamphenylborane, 2.) BF3*OEt2, 3.) aq. H2O2
With
sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; tributylphosphine; boron trifluoride diethyl etherate; potassium tert-butylate; dihydrogen peroxide; ozone; triethylamine; (+)-B-methoxydiisocamphenylborane;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo952083l
