(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:176778-23-7
Molecular Formula:C₁₃H₁₅NO₂
Molecular Weight:217.268
Hs Code.:

Synonyms:(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Chemical Property of (3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 7 articles about (3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1301725-48-3
C₁₂H₁₅NO₂

: 176778-23-7
(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis(diphenylphosphino)biphenyl; In water; toluene; at 90 ℃; for 0.5h; optical yield given as %de; Microwave irradiation; Inert atmosphere; Sealed vial;
DOI:10.1055/s-0030-1259281

Reference yield:

: (3S,8aS)-3-Phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 176778-23-7
(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 64h; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.09.014

Reference yield:

: 176694-78-3
(S)-(2,6-Dioxo-piperidin-1-yl)-phenyl-acetic acid methyl ester

: 176778-23-7
(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; Yield given. Multistep reaction; 1.) -15 deg C, MeOH, 2.) 3 h, r.t., pH 1, MeOH;
DOI:10.1080/00397919608003529