(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

Base Information

Chemical Name:(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane
CAS No.:859147-44-7
Molecular Formula:C₃₄H₄₃NO₇
Molecular Weight:577.718
Hs Code.:

Synonyms:(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

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Technology Process of (1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

There total 3 articles about (1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 859147-43-6
(1R,2R,4R)-1-tert-butoxycarbonylamino-2-hydroxy-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

: 107-30-2
chloromethyl methyl ether

: 859147-44-7
(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 23h;
DOI:10.1021/ja050732x

Reference yield:

: 859147-41-4
(1R,2R,4S)-1-tert-butoxycarbonylamino-2-hydroxy-4-hydroxymethylcyclopentane

: 859147-44-7
(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / pyridine / 0.08 h / 20 °C

2: 96 percent / DIPEA / CH₂Cl₂ / 23 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja050732x

Reference yield:

: 244057-71-4
tert-butyl N-[(1S,2R,4R,5R)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hexan-2-yl]carbamate

: 859147-44-7
(1R,2R,4R)-1-t-butoxycarbonylamino-2-(methoxymethyloxy)-4-[(6-dimethoxytrityl)oxymethyl]cyclopentane

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / Red-Al / CH₂Cl₂; toluene / 23 h / 0 °C

2: 87 percent / pyridine / 0.08 h / 20 °C

3: 96 percent / DIPEA / CH₂Cl₂ / 23 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; toluene;
DOI:10.1021/ja050732x