N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

Base Information

Chemical Name:N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide
CAS No.:356533-98-7
Molecular Formula:C₃₁H₃₄N₆O₇
Molecular Weight:602.647
Hs Code.:

Synonyms:N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

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Chemical Property of N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

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Technology Process of N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

There total 3 articles about N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 356533-97-6
N-[(1S,2R)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-2-hydroxy-1-(methylethyl)ethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

: 356533-98-7
N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

Guidance literature:: With 4-methyl-morpholine; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 - -20 ℃; for 2.5h;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 356533-98-7
N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 109 mg / N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 18 h / 20 °C

2: 98 percent / oxalyl chloride; dimethyl sulfoxide; N-methylmorpholine / CH₂Cl₂ / 2.5 h / -70 - -20 °C

With 4-methyl-morpholine; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; 2: Swern oxidation;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: 5-[(2S,1R)-2-amino-1-hydroxy-3-methylbutyl]-3-butyl-1,3,4-oxadiazolin-2-one hydrochloride

: 356533-98-7
N-[(1S)-2-(3-butyl-2-oxo-1,3,4-oxadiazolin-5-yl)-1-(methylethyl)-2-oxoethyl]-2-[5-(benzyloxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 109 mg / N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 18 h / 20 °C

2: 98 percent / oxalyl chloride; dimethyl sulfoxide; N-methylmorpholine / CH₂Cl₂ / 2.5 h / -70 - -20 °C

With 4-methyl-morpholine; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; 2: Swern oxidation;
DOI:10.1016/S0968-0896(01)00007-4