N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

Base Information

Chemical Name:N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide
CAS No.:1204670-00-7
Molecular Formula:C₁₃H₁₄F₃N₅O₃
Molecular Weight:345.281
Hs Code.:

Synonyms:N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

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Chemical Property of N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

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Technology Process of N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

There total 4 articles about N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1204669-61-3
N-hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride

: 98-16-8
3-trifluoromethylaniline

: 1204670-00-7
N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: With sodium hydrogencarbonate; In water; at 60 ℃; for 0.916667h;

Reference yield:

: N-hydroxy-4-[(2-methoxyethyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride

: 98-16-8
3-trifluoromethylaniline

: 1204670-00-7
N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1204669-59-9
4-amino-N‘-hydroxy-N-(2-methoxyethyl)-1,2,5-oxadiazole-3-carboximidamide

: 1204670-00-7
N'-hydroxy-4-[(2-methoxyethyl)amino]-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water / 15 h / 100 °C

2: sodium chloride; sodium nitrite; hydrogenchloride / water; ethyl acetate / 3 - 20 °C

3: sodium hydrogencarbonate / water / 0.92 h / 60 °C

With hydrogenchloride; sodium hydrogencarbonate; sodium chloride; potassium hydroxide; sodium nitrite; In water; ethyl acetate;