3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Base Information

Chemical Name:3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]
CAS No.:1355357-56-0
Molecular Formula:C₂₁H₂₄FNO
Molecular Weight:325.426
Hs Code.:

Synonyms:3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

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Chemical Property of 3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

Chemical Property:

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Technology Process of 3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

There total 5 articles about 3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355357-51-5
1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

: 585-71-7,38661-81-3
(1-bromoethyl)benzne

: 1355357-56-0
3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

: 1355357-55-9
1'-(4-fluorobenzyl)-3-methyl-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: 1'-benzyl-3-(fluoromethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]; With methanol; palladium 10% on activated carbon; ammonium formate; for 3h; Reflux; Inert atmosphere;

(1-bromoethyl)benzne; With potassium carbonate; In acetonitrile; at 20 ℃; Reflux;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: 398476-50-1
C₂₀H₂₃NO₂

: 1355357-56-0
3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

: 1355357-55-9
1'-(4-fluorobenzyl)-3-methyl-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1.33 h / -25 - 5 °C / Inert atmosphere

2.1: sulfuric acid; water / 19 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

4.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

5.1: methanol; palladium 10% on activated carbon; ammonium formate / 3 h / Reflux; Inert atmosphere

5.2: 20 °C / Reflux

With methanol; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; sulfuric acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; water; ammonium formate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.11.002

Reference yield:

: C₂₀H₂₃NO₂

: 1355357-56-0
3-(fluoromethyl)-1'-(1-phenylethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine]

: 1355357-55-9
1'-(4-fluorobenzyl)-3-methyl-3H-spiro[[2]benzofuran-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: methanol; palladium 10% on activated carbon; ammonium formate / 3 h / Reflux; Inert atmosphere

2.2: 20 °C / Reflux

With methanol; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; ammonium formate; In dichloromethane;
DOI:10.1016/j.bmc.2011.11.002