N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

Base Information

Chemical Name:N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine
CAS No.:169512-83-8
Molecular Formula:C₃₁H₅₂N₄O₉
Molecular Weight:624.775
Hs Code.:

Synonyms:N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

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Chemical Property of N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

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Technology Process of N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

There total 13 articles about N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-43-6,329041-72-7
4-vinylpyridine

: 169512-83-8
N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) EtOH, 80 deg C, 30 min, 2.) EtOH, 80 deg C, 3 h

2: 20percent aq. HCl / 16 h / Heating

3: H₂, AcOH / PtO₂ / methanol / 16 h / 2585.7 Torr

4: 1 N aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature

5: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

7: H₂, AcOH / 10percent Pd/C / methanol / 16 h / 2327.2 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; acetic acid; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm9801096

Reference yield:

: 1026564-84-0
4-[3-({[(S)-2-Benzyloxycarbonyl-1-((S)-1-benzyloxycarbonyl-2-cyclohexyl-ethylcarbamoyl)-ethylcarbamoyl]-methyl}-ethyl-carbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

: 169512-83-8
N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 16h; under 2327.2 Torr;
DOI:10.1021/jm9801096

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169512-83-8
N-[N-[N-(4-(N-BOC-piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-β-cyclohexylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 1 N aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

4: H₂, AcOH / 10percent Pd/C / methanol / 16 h / 2327.2 Torr

With sodium hydroxide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm9801096