3-(Aminomethyl)-4-methoxyaniline dihydrochloride

Base Information

• Chemical Name: 3-(Aminomethyl)-4-methoxyaniline dihydrochloride
• CAS No.: 102677-73-6
• Molecular Formula: C₈H₁₂N₂O*2ClH
• Molecular Weight: 225.118
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID60515246
• Mol file: 102677-73-6.mol

Synonyms:102677-73-6;3-(Aminomethyl)-4-methoxyaniline dihydrochloride;5-Amino-2-methoxy-benzenemethanamine dihydrochloride;3-(aminomethyl)-4-methoxyaniline;dihydrochloride;Benzenemethanamine, 5-amino-2-methoxy-, hydrochloride (1:2);3-(AMINOMETHYL)-4-METHOXYANILINE 2HCL;DTXSID60515246;AKOS015909090;SB80413;DS-15081;FT-0755344;O10877;F2167-4938;3-(Aminomethyl)-4-methoxyaniline--hydrogen chloride (1/2);Benzenemethanamine,5-amino-2-methoxy-,hydrochloride(1:2)

Chemical Property of 3-(Aminomethyl)-4-methoxyaniline dihydrochloride

Chemical Property:

• Vapor Pressure: 1.65E-05mmHg at 25°C
• Boiling Point: 359.4°Cat760mmHg
• Flash Point: 171.2°C
• PSA: 61.27000
• Density: g/cm³
• LogP: 3.62160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 224.0483185
• Heavy Atom Count: 13
• Complexity: 119

Purity/Quality:

99%, ^*data from raw suppliers

3-(Aminomethyl)-4-methoxyanilineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)N)CN.Cl.Cl

Technology Process of 3-(Aminomethyl)-4-methoxyaniline dihydrochloride

There total 2 articles about 3-(Aminomethyl)-4-methoxyaniline dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-Acetylamino-2-methoxy-benzyl)-2-chloro-acetamide (102677-66-7) → 3-amino-6-methoxybenzylamine dihydrochloride (102677-73-6)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

Reference yield:

4-methoxyacetanilide (51-66-1) → 3-amino-6-methoxybenzylamine dihydrochloride (102677-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96percent H₂SO₄, AcOH / 24 h / Ambient temperature

2: aq. HCl / 2 h / Heating

With hydrogenchloride; sulfuric acid; acetic acid;

Reference yield:

3-amino-6-methoxybenzylamine dihydrochloride (102677-73-6) → 7-chloro-4-<α--4-methoxy-m-toluidino>quinoline (79352-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 2 h / 100 °C / pH 4.5-5.0

2: 85 percent / Et₃N / CHCl₃ / 1.) 28 deg C, 1 h, 2.) reflux, 4 h

With triethylamine; In chloroform; water;

DOI:10.1021/jm00144a020

upstream raw materials:

N-(5-Acetylamino-2-methoxy-benzyl)-2-chloro-acetamide

4-methoxyacetanilide

Downstream raw materials:

7-chloro-4-(α-amino-4-methoxy-m-toluidino)quinoline

7-chloro-4-<α--4-methoxy-m-toluidino>quinoline

7-chloro-4-<α-amino>-4-methoxy-m-toluidino>quinoline

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