Technology Process of methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate
There total 14 articles about methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 364 mg / tetrahydrofuran / 2 h / -78 °C
2: 100 percent / NaOMe / 8 h / Ambient temperature
3: Et3N / CH2Cl2 / 1 h / 0 °C
4: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h
5: 56 percent / NaH / dimethylformamide / 14 h / 0 °C
6: 1.) NaOMe, 2.) TiCl3, NH4OAc / 1.) MeOH, room temperature, 1 h, 2.) H2O, room temperature, 2 h
With
titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 364 mg / tetrahydrofuran / 2 h / -78 °C
2: 100 percent / NaOMe / 8 h / Ambient temperature
3: Et3N / CH2Cl2 / 1 h / 0 °C
4: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h
5: 56 percent / NaH / dimethylformamide / 14 h / 0 °C
6: 1.) NaOMe, 2.) TiCl3, NH4OAc / 1.) MeOH, room temperature, 1 h, 2.) H2O, room temperature, 2 h
With
titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2 / 1 h / 0 °C
2: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h
3: 44 percent / NaH / dimethylformamide / 14 h / 0 °C
4: 1.) NaOMe, 2.) TiCl3, NH4OAc / 1.) MeOH, room temperature, 1 h, 2.) H2O, room temperature, 2 h
With
titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide;
In
dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505
