methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Base Information

Chemical Name:methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate
CAS No.:123485-13-2
Molecular Formula:C₁₈H₂₄O₄
Molecular Weight:304.386
Hs Code.:

Synonyms:methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

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Chemical Property of methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Chemical Property:

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Technology Process of methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

There total 14 articles about methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125446-62-0
2-(4'-methoxyphenyl)ethyl magnesium iodide

: 123485-13-2
methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 364 mg / tetrahydrofuran / 2 h / -78 °C

2: 100 percent / NaOMe / 8 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h

5: 56 percent / NaH / dimethylformamide / 14 h / 0 °C

6: 1.) NaOMe, 2.) TiCl₃, NH₄OAc / 1.) MeOH, room temperature, 1 h, 2.) H₂O, room temperature, 2 h

With titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505

Reference yield:

: 102631-75-4
(S)-(-)-2-Methyl-2-(2'-nitrovinyl)-δ-valerolactone

: 123485-13-2
methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 364 mg / tetrahydrofuran / 2 h / -78 °C

2: 100 percent / NaOMe / 8 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h

5: 56 percent / NaH / dimethylformamide / 14 h / 0 °C

6: 1.) NaOMe, 2.) TiCl₃, NH₄OAc / 1.) MeOH, room temperature, 1 h, 2.) H₂O, room temperature, 2 h

With titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505

Reference yield:

: 123427-82-7
methyl (3R,4S)-7-hydroxy-1-(p-methoxyphenyl)-4-methyl-3-nitromethylheptane-4-carboxylate

: 123485-13-2
methyl (1S,2S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h

3: 44 percent / NaH / dimethylformamide / 14 h / 0 °C

4: 1.) NaOMe, 2.) TiCl₃, NH₄OAc / 1.) MeOH, room temperature, 1 h, 2.) H₂O, room temperature, 2 h

With titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505