(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

Base Information

Chemical Name:(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid
CAS No.:137282-35-0
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

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Chemical Property of (S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

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Technology Process of (S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

There total 5 articles about (S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137282-34-9
(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid methyl ester

: 137282-35-0
(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1021/jm00083a005

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 137282-35-0
(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-methylmorpholine (NMM), 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, RT

2: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: tetrahydrofuran / Ambient temperature

4: 95 percent / 1 N aq. NaOH / methanol

With 4-methyl-morpholine; sodium hydroxide; sodium cyanoborohydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00083a005

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 137282-35-0
(S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-methylmorpholine (NMM), 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, RT

2: trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: tetrahydrofuran / Ambient temperature

4: 95 percent / 1 N aq. NaOH / methanol

With 4-methyl-morpholine; sodium hydroxide; sodium cyanoborohydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00083a005