N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Base Information

Chemical Name:N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
CAS No.:1402598-73-5
Molecular Formula:C₂₄H₂₀ClNO₅S₂
Molecular Weight:502.012
Hs Code.:

Synonyms:N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Chemical Property of N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Technology Process of N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

There total 5 articles about N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402599-57-8
C₃₃H₄₀ClNO₅S₂Si

: 1402598-73-5
N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: C₃₃H₄₀ClNO₅S₂Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 34h;

With water; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1402598-73-5
N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 22 h

2.1: n-butyllithium / toluene; tetrahydrofuran / 0.25 h / -78 °C

2.2: 1.5 h

3.1: hydrogenchloride; methanol / 1,4-dioxane / 1.33 h

4.1: n-butyllithium / toluene; tetrahydrofuran / 0.17 h / -78 °C

4.2: 0.25 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 34 h

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1402598-98-4
(S)-N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-2-methyl-2-propanesulfinamide

: 1402598-73-5
N-((R)-1-benzothiophen-2-yl(2-chlorophenyl)methyl)-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; methanol / 1,4-dioxane / 1.33 h

2.1: n-butyllithium / toluene; tetrahydrofuran / 0.17 h / -78 °C

2.2: 0.25 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 34 h

With hydrogenchloride; methanol; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; toluene;