Syn-α-Brom-p-chlor-acetophenon oxim

Base Information

• Chemical Name: Syn-α-Brom-p-chlor-acetophenon oxim
• CAS No.: 71426-50-1
• Molecular Formula: C₈H₇BrClNO
• Molecular Weight: 248.507
• Mol file: 71426-50-1.mol

Synonyms:Syn-α-Brom-p-chlor-acetophenon oxim

Chemical Property of Syn-α-Brom-p-chlor-acetophenon oxim

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Syn-α-Brom-p-chlor-acetophenon oxim

There total 3 articles about Syn-α-Brom-p-chlor-acetophenon oxim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-chlorobenzoylmethyl bromide (536-38-9) → Syn-α-Brom-p-chlor-acetophenon oxim (71426-50-1)

Guidance literature:

With hydroxylamine hydrochloride; In chloroform; at 20 ℃;

Reference yield:

para-chloroacetophenone (99-91-2) → Syn-α-Brom-p-chlor-acetophenon oxim (71426-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / dichloromethane / 1 h / 0 °C

2: hydroxylamine hydrochloride / water; methanol / 25 °C

With hydroxylamine hydrochloride; bromine; In methanol; dichloromethane; water;

DOI:10.1021/jo400371x

Reference yield:

→ Syn-α-Brom-p-chlor-acetophenon oxim (71426-50-1)

Guidance literature:

p-Chlor-phenacylbromid, NH2OH;

upstream raw materials:

4-chlorobenzoylmethyl bromide

para-chloroacetophenone

Downstream raw materials:

3-(4-chloro-phenyl)-isoxazol-5-ylamine

(R)-N-[1-(4-chlorophenyl)ethyl]acetamide

(Z)-1-(4-chlorophenyl)ethanone O-benzyloxime

(R)-1-(4-chlorophenyl)ethylamine

Refernces

• 1、 Fioravanti, Rossella,Biava, Mariangela,Porretta, Giulio Cesare,Lampis, Giorgio,Maullu, Carlo,Pompei, Raffaello. "Stereospecific synthesis and antimycobacterial activity of 1-aryl-2-(1H- imidazol-1-yl)-O-(aryl)-ethanoxime ethers E and Z oxiconazole analogs". . p. 249 - 266. Retrieved 2007/10/03.