(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

Base Information

Chemical Name:(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid
CAS No.:175656-26-5
Molecular Formula:C₂₅H₃₂O₃Si
Molecular Weight:408.613
Hs Code.:

Synonyms:(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

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Technology Process of (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

There total 1 articles about (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 175656-24-3
(S)-3-{(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-5-trimethylsilanyl-pent-4-ynoyl}-4-isopropyl-oxazolidin-2-one

: 175656-26-5
(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

: (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid ((S)-1-hydroxymethyl-2-methyl-propyl)-amide

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jo952092u

Reference yield:

: 175656-26-5
(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

: tert-Butyl-((3R,4S)-4-ethyl-3-isocyanato-hex-5-ynyloxy)-diphenyl-silane

Guidance literature:: With diphenyl-phosphinic acid; triethylamine; In benzene; for 3.5h; Heating;
DOI:10.1021/jo952092u

Reference yield:

: 175656-26-5
(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid

: 1026837-32-0
(2R,3R)-3-Amino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: DPPA, Et₃N / benzene / 3.5 h / Heating

2: TMSCl / CH₂Cl₂ / 96 h / Ambient temperature

3: 1.) NaHCO₃, KMnO₄, NaIO₄, 2.) KOH / 1.) t-BuOH, H₂O, rt, 3 h, 2.) THF, H₂O, rt, 2.5 h

4: H₂O / trifluoroacetic acid / 0.33 h / 0 °C

With potassium hydroxide; potassium permanganate; sodium periodate; chloro-trimethyl-silane; diphenyl-phosphinic acid; water; sodium hydrogencarbonate; triethylamine; In dichloromethane; trifluoroacetic acid; benzene;
DOI:10.1021/jo952092u