8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

Base Information

Chemical Name:8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione
CAS No.:1422054-89-4
Molecular Formula:C₃₃H₃₀N₈O₇
Molecular Weight:650.651
Hs Code.:

Synonyms:8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

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Chemical Property of 8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

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Technology Process of 8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

There total 3 articles about 8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-52-7,944357-77-1
BARBITURIC ACID

: 99-61-6
3-nitro-benzaldehyde

: 126-81-8
dimedone

: 1-(6-amino-9H-purin-9-yl)-3-phenoxypropan-2-ol

: 1422054-89-4
8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

Guidance literature:: With phosphotungstic acid; In ethanol; for 12h; Reflux;
DOI:10.1016/j.tetlet.2012.11.003

Reference yield:

: 17995-04-9
N,N-bis(trimethysilyl)adenine

: 1422054-89-4
8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

2: phosphotungstic acid / ethanol / 12 h / Reflux

With phosphotungstic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2012.11.003

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1422054-89-4
8,9-dihydro-10-(9-(2-hydroxy-3-phenoxypropyl)-9H-purin-6-yl)-8,8-dimethyl-5-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)trione

Guidance literature:: Multi-step reaction with 3 steps

1: silica sulfuric acid / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux

3: phosphotungstic acid / ethanol / 12 h / Reflux

With phosphotungstic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2012.11.003