tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate
CAS No.:1565835-98-4
Molecular Formula:C₄₃H₄₉N₇O₃S
Molecular Weight:743.973
Hs Code.:

tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1440754-34-6
1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid

: 1565835-97-3
tert-butyl 4-(2-amino-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

: 1565835-98-4
tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 1440754-29-9
ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

: 1565835-98-4
tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / methanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1565835-96-2
tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate

: 1565835-98-4
tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamido)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 72 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;