1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

Base Information

Chemical Name:1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone
CAS No.:219120-10-2
Molecular Formula:C₃₉H₅₂O₃Si
Molecular Weight:596.926
Hs Code.:

1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

Synonyms:1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

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Chemical Property of 1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

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Technology Process of 1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

There total 4 articles about 1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 219120-09-9
1-[(3S,8S,9S,10R,13R,14S,17S)-13-Allyl-10-methyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

: 219120-10-2
1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

Guidance literature:: With acetic acid; In tetrahydrofuran; water; for 1h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00106-0

Reference yield:

: 115884-43-0
3β-hydroxy-18-vinyl-20,20-ethylenedioxy-pregn-5-ene

: 219120-10-2
1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / p-TsOH / acetone / 3.5 h / Ambient temperature

2: 92 percent / PPTS / CH₂Cl₂ / 17 h / Ambient temperature

3: LDA / tetrahydrofuran / -78 - 20 °C

4: MMPP / ethanol / Ambient temperature

5: DMAP, pyridine / CH₂Cl₂ / 120 h / Ambient temperature

6: 71 percent / AcOH / H₂O; tetrahydrofuran / 1 h / Ambient temperature

With pyridine; dmap; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1016/S0968-0896(98)00106-0

Reference yield:

: 219120-06-6
3β-hydroxy-18-vinylpregn-5-en-20-one

: 219120-10-2
1-((3S,8S,9S,10R,13R,14S,17S)-13-Allyl-3-hydroxy-10-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(tert-butyl-diphenyl-silanyloxy)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / PPTS / CH₂Cl₂ / 17 h / Ambient temperature

2: LDA / tetrahydrofuran / -78 - 20 °C

3: MMPP / ethanol / Ambient temperature

4: DMAP, pyridine / CH₂Cl₂ / 120 h / Ambient temperature

5: 71 percent / AcOH / H₂O; tetrahydrofuran / 1 h / Ambient temperature

With pyridine; dmap; pyridinium p-toluenesulfonate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/S0968-0896(98)00106-0