(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

Base Information

Chemical Name:(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate
CAS No.:104619-23-0
Molecular Formula:C₂₇H₃₂N₂O₇
Molecular Weight:496.56
Hs Code.:

Synonyms:(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

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Chemical Property of (+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

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Technology Process of (+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

There total 5 articles about (+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 104619-22-9
(-)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

: 104619-23-0
(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 24h;
DOI:10.1002/jlac.198619861201

Reference yield:

: 100-44-7
benzyl chloride

: 104619-23-0
(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) glyme, 20 deg C, 15 min; 2.) 60 deg C, 2 h

2: 93 percent / 96 percent H₂SO₄ / methanol / 120 h / Heating

3: 92 percent / pyridine, DMAP / 24 h / 20 °C

With pyridine; dmap; sulfuric acid; sodium hydride; In methanol;
DOI:10.1002/jlac.198619861201

Reference yield:

: 104619-31-0
(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-1,2-O-isopropylidene-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

: 104619-23-0
(+)-(1R)-(1α,2α,3β,4α,5β,6β)-4-O-Benzyl-5-O,6-N-carbonyl-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol 1,2-Diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 96 percent H₂SO₄ / methanol / 120 h / Heating

2: 92 percent / pyridine, DMAP / 24 h / 20 °C

With pyridine; dmap; sulfuric acid; In methanol;
DOI:10.1002/jlac.198619861201