Technology Process of methyl 3-benzyloxy-5-(piperidin-1-yl)picolinate
There total 5 articles about methyl 3-benzyloxy-5-(piperidin-1-yl)picolinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
toluene;
at 90 ℃;
for 20h;
DOI:10.1016/j.tet.2011.09.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; iodine; isopentyl nitrite / diiodomethane / 0.17 h / 85 °C
2.1: TurboGrignard / tetrahydrofuran / 1 h / -20 °C
2.2: 0.5 h / -20 °C
3.1: iodine; potassium hydroxide / 0 °C
4.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 20 h / 90 °C
With
tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; TurboGrignard; iodine; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; isopentyl nitrite;
In
tetrahydrofuran; diiodomethane; toluene;
4.1: Hartwig-Buchwald reaction;
DOI:10.1016/j.tet.2011.09.024
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 20 °C
1.2: 3.58 h / 0 °C
2.1: copper(l) iodide; iodine; isopentyl nitrite / diiodomethane / 0.17 h / 85 °C
3.1: TurboGrignard / tetrahydrofuran / 1 h / -20 °C
3.2: 0.5 h / -20 °C
4.1: iodine; potassium hydroxide / 0 °C
5.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 20 h / 90 °C
With
tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; TurboGrignard; sulfuric acid; iodine; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; isopentyl nitrite;
In
tetrahydrofuran; diiodomethane; toluene;
5.1: Hartwig-Buchwald reaction;
DOI:10.1016/j.tet.2011.09.024
