2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

Base Information

Chemical Name:2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide
CAS No.:1207961-24-7
Molecular Formula:C₂₃H₂₂Cl₃N₇O₂
Molecular Weight:534.832
Hs Code.:

2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

Synonyms:2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

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Chemical Property of 2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

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Technology Process of 2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

There total 15 articles about 2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1046861-46-4
Imidazole-1-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

: 1207961-41-8
4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)-ethoxy]-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine

: 1207961-24-7
2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield:

: 1028332-19-5
3,5-dichloro-2-iodophenol

: 1207961-24-7
2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3.2: Cooling

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.67 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 23 °C

7.1: triethylamine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 75 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; CyJohnPhos; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm200128m

Reference yield:

: 1028332-20-8
1,5-dichloro-3-(ethoxymethoxy)-2-iodobenzene

: 1207961-24-7
2-amino-4-{2,4-dichloro-6-[2-(4-chloropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: Cooling

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.67 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 23 °C

6.1: triethylamine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 75 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; CyJohnPhos; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/jm200128m