tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

Base Information

Chemical Name:tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate
CAS No.:1422157-35-4
Molecular Formula:C₁₈H₂₇O₇PS
Molecular Weight:418.448
Hs Code.:

Synonyms:tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

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Chemical Property of tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

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Technology Process of tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

There total 4 articles about tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1422157-34-3
tert-butyl (+)-(1R,2R,S_S)-1-dimethylphosphono-2-(p-tolylsulfinyl)-2-methylcyclopropane-1-carboxylate

: 1422157-35-4
tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Inert atmosphere;
DOI:10.1002/ejoc.201600111

Reference yield:

: 1422157-33-2
tert-butyl (+)-(1R,2S,R_S)-1-dimethylphosphono-2-(p-tolylsulfinyl)cyclopropane-1-carboxylate

: 1422157-35-4
tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.25 h / -70 °C / Inert atmosphere

1.2: -70 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.201600111

Reference yield:

: (S)-dimethylsulfonium-(p-tolylsulfinyl)methyl tetrafluoroborate

: 1422157-35-4
tert-butyl (+)-(1R,2R)-1-dimethylphosphono-2-(p-tolylsulfonyl)-2-methylcyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dichloromethane / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.25 h / -70 °C / Inert atmosphere

2.2: -70 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Inert atmosphere

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.201600111