(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

Base Information

Chemical Name:(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one
CAS No.:1304755-28-9
Molecular Formula:C₁₇H₁₅BrN₂O₅S
Molecular Weight:439.287
Hs Code.:

Synonyms:(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

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Chemical Property of (R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

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Technology Process of (R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

There total 7 articles about (R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1304754-56-0
(R)-2-(bromomethyl)-1-(4-nitrophenylsulfonyl)-2-phenylpyrrolidine

: 1304755-28-9
(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

Guidance literature:: With potassium permanganate; copper(ll) sulfate pentahydrate; In dichloromethane; for 72h; Reflux;
DOI:10.1021/ja201627h

Reference yield:

: 194805-62-4
methyl-4-bromo-pent-4-enoate

: 1304755-28-9
(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 25 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 100 °C

4.2: 1 h / 100 °C

5.1: N-Bromosuccinimide; C₃₅H₄₅N₃O₄S / chloroform / 60 h / -62 °C / Inert atmosphere; Darkness

6.1: potassium permanganate; copper(ll) sulfate pentahydrate / dichloromethane / 72 h / Reflux

With potassium permanganate; N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(ll) sulfate pentahydrate; C₃₅H₄₅N₃O₄S; sodium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ja201627h

Reference yield:

: 1304753-57-8
4-nitro-N-(4-phenylpent-4-en-1-yl)benzenesulfonamide

: 1304755-28-9
(R)-5-(bromomethyl)-1-(4-nitrophenylsulfonyl)-5-phenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; C₃₅H₄₅N₃O₄S / chloroform / 60 h / -62 °C / Inert atmosphere; Darkness

2: potassium permanganate; copper(ll) sulfate pentahydrate / dichloromethane / 72 h / Reflux

With potassium permanganate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; C₃₅H₄₅N₃O₄S; In dichloromethane; chloroform;
DOI:10.1021/ja201627h