pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

Base Information

Chemical Name:pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate
CAS No.:1438852-80-2
Molecular Formula:C₃₆H₃₉F₅N₂O₆
Molecular Weight:690.707
Hs Code.:

Synonyms:pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

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Chemical Property of pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

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Technology Process of pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

There total 8 articles about pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 14533-84-7
pentafluorophenyl trifloroacetate

: 1438851-41-2
(3R,4S,5S)-4-[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoic acid

: 1438852-80-2
pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 120294-43-1
tert-Butyl (3R,4S,5S)-3-hydroxy-4--5-methylheptanoate

: 1438852-80-2
pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trimethoxonium tetrafluoroborate / 1,2-dichloro-ethane / Molecular sieve

2: palladium 10% on activated carbon; hydrogen; hydrogenchloride / methanol / 3 h / 2327.23 Torr / Inert atmosphere

3: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / 2-methyltetrahydrofuran / 3 h

4: trifluoroacetic acid / dichloromethane

5: pyridine / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; palladium 10% on activated carbon; hydrogen; trimethoxonium tetrafluoroborate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trifluoroacetic acid; In 2-methyltetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 120205-58-5
tert-Butyl (3R,4S,5S)-3-methoxy-4--5-methylheptanoate

: 1438852-80-2
pentafluorophenyl (3R,4S,5S)-4-[{N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / methanol / 3 h / 2327.23 Torr / Inert atmosphere

2: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / 2-methyltetrahydrofuran / 3 h

3: trifluoroacetic acid / dichloromethane

4: pyridine / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In 2-methyltetrahydrofuran; methanol; dichloromethane;