C₂₁H₁₈FNO₅S

Base Information Edit

Chemical Name:C₂₁H₁₈FNO₅S
CAS No.:1374233-37-0
Molecular Formula:C₂₁H₁₈FNO₅S
Molecular Weight:415.442
Hs Code.:
Mol file:1374233-37-0.mol

C<sub>21</sub>H<sub>18</sub>FNO<sub>5</sub>S

Synonyms:C₂₁H₁₈FNO₅S

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Chemical Property of C₂₁H₁₈FNO₅S Edit

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Technology Process of C₂₁H₁₈FNO₅S

There total 7 articles about C₂₁H₁₈FNO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1374233-36-9
C₂₃H₂₂FNO₅S

: 1374233-37-0
C₂₁H₁₈FNO₅S

Guidance literature:: C₂₃H₂₂FNO₅S; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 75 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; pH=5 - 6;

Reference yield:

: 691857-07-5
ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1374233-37-0
C₂₁H₁₈FNO₅S

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4.1: boron trichloride / dichloromethane / 0.5 h / -30 - -20 °C

4.2: Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.33 h / 0 °C

6.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 75 °C

7.2: 20 °C / pH 5 - 6

With water; hydrogen; boron trichloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; dmap; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1374233-33-6
C₂₆H₃₀FNO₆S

: 1374233-37-0
C₂₁H₁₈FNO₅S

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trichloride / dichloromethane / 0.5 h / -30 - -20 °C

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0.33 h / 0 °C

3.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 75 °C

4.2: 20 °C / pH 5 - 6

With water; boron trichloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; dmap; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;