(S)-5-Heptyl-1-phenyl-pyrrolidin-2-one

Base Information

• Chemical Name: (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one
• CAS No.: 119690-98-1
• Molecular Formula: C₁₇H₂₅NO
• Molecular Weight: 259.392
• Mol file: 119690-98-1.mol

Synonyms:(S)-5-Heptyl-1-phenyl-pyrrolidin-2-one

Chemical Property of (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one

There total 14 articles about (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-5-Heptyl-1-phenyl-1,5-dihydro-pyrrol-2-one → (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one (119690-98-1)

Guidance literature:

With hydrogen; 5% platinum on alumina; In tert-butyl alcohol; for 4h; Ambient temperature;

DOI:10.1248/cpb.40.1670

Reference yield:

n-heptylmagnesium bromide (13125-66-1) → (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one (119690-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / ZnBr₂ / diethyl ether; xylene / 2.5 h / Ambient temperature

2: 71 percent / xylene / 0.5 h / 160 °C

3: 96 percent / H₂ / Pt-alumina / 2-methyl-propan-2-ol / 4 h / Ambient temperature

With hydrogen; zinc dibromide; 5% platinum on alumina; In diethyl ether; xylene; tert-butyl alcohol;

DOI:10.1248/cpb.40.1670

Reference yield:

(1R,2S,5S,6R,7S)-5-Hydroxy-4-phenyl-4-aza-tricyclo[5.2.1.02,6]dec-8-en-3-one (58684-83-6) → (S)-5-Heptyl-1-phenyl-pyrrolidin-2-one (119690-98-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / pyridinium p-toluenesulfonate / 12 h / Ambient temperature

2: 77 percent / CaCl₂ / CH₂Cl₂ / 12 h / Ambient temperature

3: 83 percent / ZnBr₂ / tetrahydrofuran / 14 h / Ambient temperature

4: 76 percent / 450 °C / 0 Torr

5: 96 percent / H₂ / Pt-alumina / 2-methyl-propan-2-ol / 4 h / Ambient temperature

With hydrogen; pyridinium p-toluenesulfonate; calcium chloride; zinc dibromide; 5% platinum on alumina; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;

DOI:10.1248/cpb.40.1670

upstream raw materials:

n-heptylmagnesium bromide

(1R,2S,5S,6R,7S)-5-Hydroxy-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-3-one

1,2-epoxynonane

Acetanilid