4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid

Base Information

Chemical Name:4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid
CAS No.:223465-83-6
Molecular Formula:C₁₉H₁₇NO₄
Molecular Weight:323.348
Hs Code.:
DSSTox Substance ID:DTXSID501235239

Synonyms:SCHEMBL7740305;DTXSID501235239;4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid;223465-83-6

Suppliers and Price of 4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid

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Chemical Property of 4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:323.11575802
Heavy Atom Count:24
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(O2)C3=CC=C(C=C3)C(=O)NCCCC(=O)O

Technology Process of 4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid

There total 5 articles about 4-[[4-(2-Benzofuranyl)benzoyl]amino]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223465-82-5
ethyl 4-{[4-(1-benzofuran-2-yl)benzoyl]amino}butanoate

: 223465-83-6
4-{[4-(1-benzofuran-2-yl)benzoyl]amino}butanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 223465-83-6
4-{[4-(1-benzofuran-2-yl)benzoyl]amino}butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 70 percent / triethylamine; 1-hydroxybenzotriazole monohydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / dimethylformamide / 48 h / 20 °C

4: sodium hydroxide / tetrahydrofuran; H₂O / 3 h / 20 °C

With sodium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 223465-83-6
4-{[4-(1-benzofuran-2-yl)benzoyl]amino}butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 70 percent / triethylamine; 1-hydroxybenzotriazole monohydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / dimethylformamide / 48 h / 20 °C

4: sodium hydroxide / tetrahydrofuran; H₂O / 3 h / 20 °C

With sodium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032