9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro

Base Information

• Chemical Name: 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro
• CAS No.: 89889-46-3
• Molecular Formula: C₂₂H₁₈O
• Molecular Weight: 298.384
• Mol file: 89889-46-3.mol

Synonyms:9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro

Chemical Property of 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro

There total 3 articles about 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Spiro-10-one (887-26-3) + phenyllithium (591-51-5) → 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro (89889-46-3)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1021/ja00323a034

Reference yield:

C16H12N2O → 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro (89889-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / Heating

2: 79 percent / tetrahydrofuran / Heating

In tetrahydrofuran; chloroform;

DOI:10.1021/ja00323a034

Reference yield:

Spiro-10-one (887-26-3) + phenylmagnesium bromide → 9,10-Dihydro-9-phenyl-9-hydroxy-10-spiro (89889-46-3)

Guidance literature:

With diethyl ether; benzene;

DOI:10.1039/jr9520001434

upstream raw materials:

Spiro-10-one

phenyllithium