Technology Process of (R,R,R,R)-N(1)-benzyl-2-[(triisopropylsilyloxy)methyl]-3-benzyloxy-4,5-diacetoxypiperidine
There total 7 articles about (R,R,R,R)-N(1)-benzyl-2-[(triisopropylsilyloxy)methyl]-3-benzyloxy-4,5-diacetoxypiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dmap;
at 0 - 20 ℃;
for 16h;
DOI:10.1021/ol400735z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
2.1: iodine / water; 1,4-dioxane / 16 h / 20 °C
2.2: 16 h / 0 - 20 °C
3.1: potassium carbonate / methanol / 16 h / 20 °C
4.1: pyridine; dmap / 16 h / 0 - 20 °C
With
pyridine; dmap; iodine; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/ol400735z
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
3.1: iodine / water; 1,4-dioxane / 16 h / 20 °C
3.2: 16 h / 0 - 20 °C
4.1: potassium carbonate / methanol / 16 h / 20 °C
5.1: pyridine; dmap / 16 h / 0 - 20 °C
With
pyridine; dmap; oxalyl dichloride; iodine; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/ol400735z
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