3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

Base Information

Chemical Name:3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid
CAS No.:1071794-97-2
Molecular Formula:C₂₆H₁₈Cl₂N₂O₃S₂
Molecular Weight:541.479
Hs Code.:

Synonyms:3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

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Chemical Property of 3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

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Technology Process of 3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

There total 9 articles about 3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071795-09-9
methyl 3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecarboxylate

: 1071794-97-2
3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

Guidance literature:: methyl 3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecarboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; water; pH=1.0;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1071794-97-2
3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / dichloromethane / 20 °C

1.2: 24.5 h / 20 °C

2.1: pyridine / 70 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0 °C

3.2: 0.5 h / -78 - -65 °C

3.3: 1.5 h / -65 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 110 °C / Microwave irradiation

5.1: methanol; lithium hydroxide; water / tetrahydrofuran / 24 h / 20 °C

5.2: pH 1.0

With pyridine; methanol; lithium hydroxide; n-butyllithium; water; sodium carbonate; acetic acid; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;

Reference yield:

: 630094-87-0
trimethyl(2-thiazol-4-ylethynyl)silane

: 1071794-97-2
3-[[(2,4-dichlorophenyl)carbonyl](1-methylethyl)amino]-5-[4-(1,3-thiazol-4-ylethynyl)phenyl]-2-thiophenecaboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; potassium hydroxide; water / 3 h

2.1: potassium acetate; triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dichloromethane / 3 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 110 °C / Microwave irradiation

4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 24 h / 20 °C

4.2: pH 1.0

With methanol; potassium hydroxide; lithium hydroxide; water; potassium acetate; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;