methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate

Base Information

• Chemical Name: methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate
• CAS No.: 472966-61-3
• Molecular Formula: C₂₇H₃₁N₂O₆P
• Molecular Weight: 510.527
• Mol file: 472966-61-3.mol

Synonyms:methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate

Chemical Property of methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate

There total 6 articles about methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

L-valine methylester hydrochloride (6306-52-1) + C21H19ClNO4P → methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate (472966-61-3)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1016/S0040-4020(02)00561-6

Reference yield:

triphenyl phosphite (101-02-0) → methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate (472966-61-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / AcOH

2: 86 percent / NaOH; 18-crown-6; potassium fluoride / dioxane / pH 1

3: SOCl₂ / benzene / 2 h / Heating

4: 48 percent / triethylamine / CHCl₃ / 20 °C

With potassium fluoride; sodium hydroxide; thionyl chloride; 18-crown-6 ether; acetic acid; triethylamine; In 1,4-dioxane; chloroform; benzene;

DOI:10.1016/S0040-4020(02)00561-6

Reference yield:

O-benzyl carbamate (621-84-1) → methyl N-[[{[(benzyloxy)carbonyl]amino}(phenyl)methyl](phenoxy)phosphoryl]-L-valinate (472966-61-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / AcOH

2: 86 percent / NaOH; 18-crown-6; potassium fluoride / dioxane / pH 1

3: SOCl₂ / benzene / 2 h / Heating

4: 48 percent / triethylamine / CHCl₃ / 20 °C

With potassium fluoride; sodium hydroxide; thionyl chloride; 18-crown-6 ether; acetic acid; triethylamine; In 1,4-dioxane; chloroform; benzene;

DOI:10.1016/S0040-4020(02)00561-6

upstream raw materials:

L-valine methylester hydrochloride

triphenyl phosphite

O-benzyl carbamate

O,O-diphenyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate