3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

Base Information

Chemical Name:3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide
CAS No.:1025992-21-5
Molecular Formula:C₁₉H₁₄N₂O₄S
Molecular Weight:366.397
Hs Code.:

Synonyms:3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

Suppliers and Price of 3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

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Technology Process of 3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

There total 5 articles about 3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-44-3
3-nitro-L-tyrosine

: 1025992-21-5
3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂, KBr, aq. 3 N H₂SO₄ / 0.17 h

2: AcONa / ethanol / 3 h / Heating

3: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

4: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

5: PhNMe₂ / tetrahydrofuran; dimethylformamide

With hydrogenchloride; sulfuric acid; hydrogen; sodium acetate; N,N-dimethyl-aniline; potassium bromide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-65-6
2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid

: 1025992-21-5
3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: AcONa / ethanol / 3 h / Heating

2: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

3: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

4: PhNMe₂ / tetrahydrofuran; dimethylformamide

With hydrogenchloride; hydrogen; sodium acetate; N,N-dimethyl-aniline; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-66-7
5-(4-hydroxy-3-nitrobenzyl)-2-imino-4-oxothiazolidine

: 1025992-21-5
3-Phenyl-propynoic acid [5-(2,4-dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

3: PhNMe₂ / tetrahydrofuran; dimethylformamide

With hydrogenchloride; hydrogen; N,N-dimethyl-aniline; palladium on activated charcoal; In tetrahydrofuran; methanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984