2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

Base Information

Chemical Name:2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol
CAS No.:873324-81-3
Molecular Formula:C₂₂H₂₉ClN₂O₄
Molecular Weight:420.936
Hs Code.:

Synonyms:2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

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Chemical Property of 2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

Chemical Property:

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Technology Process of 2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

There total 3 articles about 2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873324-80-2
1-{3-[2-(tert-Butyldimethylsilanyloxy)-ethoxy]-4-chloro-phenyl}-4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazine

: 873324-81-3
2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

Guidance literature:: With water; toluene-4-sulfonic acid; In tetrahydrofuran; for 48h; Heating / reflux;

Reference yield:

: 873324-79-9
[2-(5-bromo-2-chloro-phenoxy)-ethoxy]-tert-butyldimethylsilane

: 873324-81-3
2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 90 °C

2: water; toluene-4-sulfonic acid / tetrahydrofuran / 48 h / Heating / reflux

With potassium tert-butylate; water; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; toluene;

Reference yield:

: 183802-98-4
5-bromo-2-chlorophenol

: 873324-81-3
2-(2-Chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 90 °C

3: water; toluene-4-sulfonic acid / tetrahydrofuran / 48 h / Heating / reflux

With di-isopropyl azodicarboxylate; potassium tert-butylate; water; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; toluene; 1: Mitsunobu reaction;