1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

Base Information

Chemical Name:1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]
CAS No.:1314970-59-6
Molecular Formula:C₁₉H₁₉N
Molecular Weight:261.367
Hs Code.:

Synonyms:1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

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Chemical Property of 1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

Chemical Property:

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Technology Process of 1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

There total 7 articles about 1'-benzylspiro[cyclopent-3-ene-1,3'-indoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1314970-58-5
1'-(2-bromobenzyl)spiro[cyclopent-3-ene-1,3'-indoline]

: 1314970-59-6
1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

Guidance literature:: With tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In toluene; for 18h; Reflux; Inert atmosphere;
DOI:10.1039/c1ob05527e

Reference yield:

: 1314970-47-2
3,3-diallyl-1-(2-bromobenzyl)indolin-2-one

: 1314970-59-6
1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

Guidance literature:: Multi-step reaction with 3 steps

1.1: Hoveyda-Grubbs catalyst second generation / toluene / 22 h / Inert atmosphere; Reflux

2.1: aluminium hydride / toluene / 4.33 h / -78 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

3.1: tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile) / toluene / 18 h / Reflux; Inert atmosphere

With aluminium hydride; Hoveyda-Grubbs catalyst second generation; tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile); In toluene;
DOI:10.1039/c1ob05527e

Reference yield:

: 689757-55-9
1-(2-bromobenzyl)-1H-indole-2,3-dione

: 1314970-59-6
1'-benzylspiro[cyclopent-3-ene-1,3'-indoline]

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / Inert atmosphere

2.2: 16 h / Inert atmosphere

3.1: Hoveyda-Grubbs catalyst second generation / toluene / 22 h / Inert atmosphere; Reflux

4.1: aluminium hydride / toluene / 4.33 h / -78 °C / Inert atmosphere

4.2: 0.17 h / Inert atmosphere

5.1: tri-n-butyl-tin hydride; 1,1'-azobis(1-cyanocyclohexanenitrile) / toluene / 18 h / Reflux; Inert atmosphere

With aluminium hydride; Hoveyda-Grubbs catalyst second generation; tri-n-butyl-tin hydride; sodium hydride; hydrazine hydrate; 1,1'-azobis(1-cyanocyclohexanenitrile); In N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c1ob05527e