(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine
CAS No.:1361970-00-4
Molecular Formula:C₂₂H₃₃NO₃S
Molecular Weight:391.575
Hs Code.:

Synonyms:(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

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Technology Process of (2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

There total 6 articles about (2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1361969-89-2
N-((R)-hept-1-yn-4-yl)-4-methyl-N-((R)-1-(pentyloxy)allyl)benzenesulfonamide

: 1361970-00-4
(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

Guidance literature:: With 2,6-di-tert-butyl-pyridine; Au+(CH₃CN)[(tert-butyl)2P((o-Ph)Ph)]SbF₆-; In dichloromethane; at 20 ℃; optical yield given as %de; Inert atmosphere; sealed tube;
DOI:10.1021/ja2116298

Reference yield:

: 1361969-52-9
(R)-4-methyl-N-(1-(trimethylsilyl)hept-1-yn-4-yl)benzenesulfonamide

: 1361970-00-4
(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); palladium diacetate; triethylamine / dichloromethane / 13 h / 20 °C / sealed tube; Inert atmosphere

2: potassium carbonate / methanol / 20 °C / sealed tube; Inert atmosphere

3: 2,6-di-tert-butyl-pyridine; Au+(CH₃CN)[(tert-butyl)2P((o-Ph)Ph)]SbF₆- / dichloromethane / 20 °C / Inert atmosphere; sealed tube

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); 2,6-di-tert-butyl-pyridine; Au+(CH₃CN)[(tert-butyl)2P((o-Ph)Ph)]SbF₆-; palladium diacetate; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/ja2116298

Reference yield:

: 1361969-71-2
4-methyl-N-((R)-1-(pentyloxy)allyl)-N-((R)-1-(trimethylsilyl)hept-1-yn-4-yl)benzenesulfonamide

: 1361970-00-4
(2R,6S)-4-(pentyloxy)-2-propyl-1-tosyl-6-vinyl-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 20 °C / sealed tube; Inert atmosphere

2: 2,6-di-tert-butyl-pyridine; Au+(CH₃CN)[(tert-butyl)2P((o-Ph)Ph)]SbF₆- / dichloromethane / 20 °C / Inert atmosphere; sealed tube

With 2,6-di-tert-butyl-pyridine; Au+(CH₃CN)[(tert-butyl)2P((o-Ph)Ph)]SbF₆-; potassium carbonate; In methanol; dichloromethane;
DOI:10.1021/ja2116298