4-(2-Piperidylethoxy)benzophenone

Base Information

• Chemical Name: 4-(2-Piperidylethoxy)benzophenone
• CAS No.: 102156-42-3
• Molecular Formula: C20H23 N O2
• Molecular Weight: 309.4
• DSSTox Substance ID: DTXSID00699059
• Mol file: 102156-42-3.mol

Synonyms:102156-42-3;4-(2-PIPERIDYLETHOXY)BENZOPHENONE;4-(PIPERIDIN-2-YLETHOXY)BENZOPHENONE;phenyl-[4-(2-piperidin-2-ylethoxy)phenyl]methanone;SCHEMBL7335065;DTXSID00699059;Phenyl{4-[2-(piperidin-2-yl)ethoxy]phenyl}methanone

Chemical Property of 4-(2-Piperidylethoxy)benzophenone

Chemical Property:

• PSA: 38.33000
• LogP: 4.15740
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 309.172878976
• Heavy Atom Count: 23
• Complexity: 357

Purity/Quality:

95% ^*data from raw suppliers

4-(2-PIPERIDYLETHOXY)BENZOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CCOC2=CC=C(C=C2)C(=O)C3=CC=CC=C3

Technology Process of 4-(2-Piperidylethoxy)benzophenone

There total 2 articles about 4-(2-Piperidylethoxy)benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-chloroethylpiperidine hydrochloride (2008-75-5) + 4-Hydroxybenzophenone (1137-42-4) → 4-(piperidinylethoxy)benzophenone (102156-42-3)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1021/jm001119l

Reference yield:

→ 4-(piperidinylethoxy)benzophenone (102156-42-3)

Guidance literature:

4-Hydroxy-benzophenon, 2-Piperidino-ethylchlorid, Na-Methylat, sd. EtOH, Toluol;

Reference yield: 24.0%

benzyl ethyl ketone (1007-32-5) + 4-(piperidinylethoxy)benzophenone (102156-42-3) → 2-benzyl-1-phenyl-1-[4-(piperidinylethoxy)phenyl]but-1-ene

Guidance literature:

With titanium tetrachloride; zinc; In 1,4-dioxane; for 4h; Heating;

DOI:10.1021/jm001119l

upstream raw materials:

N-chloroethylpiperidine hydrochloride

4-Hydroxybenzophenone

Refernces

• 1、 Bal-Tembe, Swati,Bhedi, Dilip N.,Mishra, Anil K.,Rajagopalan, Ramanujam,Ghate, Anil V.,Subbarayan, Palakodety,Punekar, Narayan S.,Kulkarni, Anjali V.. "HL 752: A potent and long-acting antispasmodic agent". . p. 1381 - 1387. Retrieved 2007/10/03.