(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

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Chemical Name:(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
CAS No.:159333-24-1
Molecular Formula:C₂₆H₂₆N₆O₃
Molecular Weight:470.531
Hs Code.:

Synonyms:(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

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Chemical Property of (3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

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Technology Process of (3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

There total 14 articles about (3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 34897-85-3
o-azidobenzoyl chloride

: 159333-23-0
DKP

: 159333-24-1
(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00103a034

Reference yield: 44.0%

: 1092387-25-1
C₂₀H₂₃N₃O₃

: o-azidobenzoic anhydride

: 1092387-26-2
C₂₇H₂₆N₆O₄

: 159333-24-1
(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Guidance literature:: C₂₀H₂₃N₃O₃; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

o-azidobenzoic anhydride; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/jo802216z

Reference yield: 17.0%

: 1092387-29-5
C₂₀H₂₃N₃O₃

: o-azidobenzoic anhydride

: 1092387-26-2
C₂₇H₂₆N₆O₄

: 159333-24-1
(3R,5aS,10bR,11aS)-2-(2-Azido-benzoyl)-10b-(1,1-dimethyl-allyl)-3-methyl-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Guidance literature:: C₂₀H₂₃N₃O₃; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

o-azidobenzoic anhydride; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/jo802216z