{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

Base Information

Chemical Name:{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid
CAS No.:132541-57-2
Molecular Formula:C₁₁H₁₁N₂O₅P
Molecular Weight:282.192
Hs Code.:

Synonyms:{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

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Chemical Property of {[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

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Technology Process of {[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

There total 4 articles about {[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 132541-53-8
{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid di-tert-butyl ester

: 132541-57-2
{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 0.75h; Ambient temperature;
DOI:10.1021/jm00109a008

Reference yield:

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 132541-57-2
{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / basic alumina oxide / Ambient temperature

2: 100 percent / aq. HCl / CHCl₃ / 0.33 h / Ambient temperature

3: 55 percent / piperidine / toluene / Ambient temperature

4: 85 percent / anisole, trifluoroacetic acid / CH₂Cl₂ / 0.75 h / Ambient temperature

With piperidine; hydrogenchloride; aluminum oxide; methoxybenzene; trifluoroacetic acid; In dichloromethane; chloroform; toluene;
DOI:10.1021/jm00109a008

Reference yield:

: 132541-46-9
bis(1,1-dimethylethyl) <(4-formylphenyl)hydroxymethyl>phosphonate

: 132541-57-2
{[4-((E)-2-Carbamoyl-2-cyano-vinyl)-phenyl]-hydroxy-methyl}-phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / piperidine / toluene / Ambient temperature

2: 85 percent / anisole, trifluoroacetic acid / CH₂Cl₂ / 0.75 h / Ambient temperature

With piperidine; methoxybenzene; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jm00109a008