Technology Process of benzyl 2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl carbamate
There total 13 articles about benzyl 2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; potassium nitrate / 24 h / 0 - 20 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C
3.1: sodium azide / dichloromethane / 0.5 h / 20 °C
3.2: 3 h / Reflux
4.1: palladium on activated charcoal; hydrogen / methanol / 15 h
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C
6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C
7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
With
hydrogenchloride; sodium azide; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / dichloromethane / 0.5 h / 20 °C
1.2: 3 h / Reflux
2.1: palladium on activated charcoal; hydrogen / methanol / 15 h
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C
4.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
With
hydrogenchloride; sodium azide; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / ethyl acetate / 0.1 h / 90 °C
2: potassium acetate; bis(triphenylylphosphine)palladium(II) dichloride / ethanol; water / 2 h / 80 °C / Inert atmosphere; Reflux
3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
With
bis(triphenylylphosphine)palladium(II) dichloride; potassium acetate; toluene-4-sulfonic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
