(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

Base Information

Chemical Name:(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one
CAS No.:343782-87-6
Molecular Formula:C₃₁H₃₆O₅Si
Molecular Weight:516.709
Hs Code.:

Synonyms:(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

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Chemical Property of (S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

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Technology Process of (S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

There total 12 articles about (S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 880344-84-3
Acrylic acid (S)-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-but-3-enyl ester

: 343782-87-6
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; for 4h; Heating;
DOI:10.1021/ja0547477

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 880344-65-0
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-5,6-dihydro-pyran-2-one

: 343782-87-6
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With trityl tetrafluoroborate; In diethyl ether; at 0 ℃; for 0.333333h;
DOI:10.1002/1521-3773(20010401)40:7<1262::AID-ANIE1262>3.0.CO;2-9

Reference yield:

: 866454-44-6
(2R)-3-[(tert-butyldiphenylsilyl)oxy]-2-(4-methoxybenzyloxy)propanal

: 343782-87-6
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / diethyl ether / 2 h / -100 °C

2: 78 percent / 4-dimethylaminopyridine; DCC / CH₂Cl₂ / 4 h / Heating

3: 91 percent / Grubbs first generation catalyst / CH₂Cl₂ / 4 h / Heating

With dmap; Grubbs catalyst first generation; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/ja0547477