3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

Base Information

Chemical Name:3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate
CAS No.:1228121-73-0
Molecular Formula:C₂₅H₃₉NO₆Si
Molecular Weight:477.673
Hs Code.:

Synonyms:3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

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Chemical Property of 3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

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Technology Process of 3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

There total 1 articles about 3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1195764-25-0
tert-butyl (2R,3S)-5-(tert-butyldimethylsilyloxy)-2-methyl-6-oxopiperidine-1-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1228121-74-1
tert-butyl (5S,6R)-2-(benzyloxycarbonyloxy)-5-(tert-butyldimethylsilyloxy)-6-methyl-4,5-dihydropyridine-1-carboxylate

: 1228121-73-0
3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

Guidance literature:: tert-butyl (2R,3S)-5-(tert-butyldimethylsilyloxy)-2-methyl-6-oxopiperidine-1-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

benzyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/jo100744c

Reference yield: 87.0%

: 34837-55-3
Phenylselenyl bromide

: 1228121-73-0
3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate

: 1228121-75-2
3-benzyl 1-tert-butyl (5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxo-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Guidance literature:: 3-benzyl 1-tert-butyl (3S,5S,6R)-5-(tert-butyldimethylsilyloxy)-6-methyl-2-oxopiperidine-1,3-dicarboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

Phenylselenyl bromide; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

With dihydrogen peroxide; In dichloromethane; water;
DOI:10.1021/jo100744c