(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

Base Information

Chemical Name:(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine
CAS No.:366786-62-1
Molecular Formula:C₂₄H₃₁NO₆S
Molecular Weight:461.579
Hs Code.:

Synonyms:(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

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Chemical Property of (2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

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Technology Process of (2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

There total 3 articles about (2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 366786-61-0
(2S,5S)-1-tert-butoxycarbonyl-2-tert-butyldimethylsilyloxymethyl-3-phenylsulfonyl-5-benzyloxymethyl pyrrolidine

: 366786-62-1
(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(01)00537-3

Reference yield:

: 253776-34-0
(2S)-1-O-benzylglycerol-2,3-bis(trifluoromethanesulfonate)

: 366786-62-1
(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 2.31 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)00537-3

Reference yield:

: [1-benzenesulfonylmethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester

: 366786-62-1
(2S,5S)-1-tert-butoxycarbonyl-2-hydroxymethyl-3-phenylsulfonyl-5-benzyloxy-methyl pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 2.31 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)00537-3