1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

Base Information

Chemical Name:1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one
CAS No.:1311271-22-3
Molecular Formula:C₁₈H₂₅BrO₅
Molecular Weight:401.297
Hs Code.:

Synonyms:1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

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Chemical Property of 1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

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Technology Process of 1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

There total 3 articles about 1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5-bromo-4-methoxy-2-methoxymethoxybenzaldehyde

: 110-93-0,129085-68-3
6-Methyl-hept-5-en-2-on

: 1311271-22-3
1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

Guidance literature:: 6-Methyl-hept-5-en-2-on; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

5-bromo-4-methoxy-2-methoxymethoxybenzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With water; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1016/j.tet.2011.03.059

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1311271-22-3
1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; acetic acid / 1 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 1 h / -78 °C

3.3: -78 °C

With bromine; sodium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.03.059

Reference yield:

: 57543-36-9
5-bromo-2-hydroxy-4-methoxybenzaldehyde

: 1311271-22-3
1-(5-bromo-4-methoxy-2-(methoxymethoxy)phenyl)-1-hydroxy-7-methyloct-6-en-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 1 h / -78 °C

2.3: -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2011.03.059